Abstract: Commiphora mukul, also called guggul, is a plant that makes resin as well as is often used in Ayurvedic medicine because it has multiple medicinal benefits. This review thoroughly explores its detailed taxonomy, common distribution, along with thorough phytochemistry, meaningful pharmacological activities, as well as diverse medicinal applications. The plant has bioactive ingredients such as guggulsterones, diterpenoids, and necessary oils, and these contribute to its effects against conditions like inflammation, high cholesterol, obesity, and arthritis. Its therapeutic effectiveness in the treatment of many metabolic conditions, cardiovascular ailments, and multiple skin problems is completely confirmed by well-known customary and scientific research. Different removal methods improve how well the body can use it. This makes it a helpful, natural treatment in current healthcare.

Keywords: Commiphora mukul, Guggul, Phytochemistry, Pharmacological activities, Medicinal applications, Metabolic disorders, Ayurvedic medicine.