DESIGN AND CHARACTERIZATION OF SWIETENIA MAHAGONI Jacq. MEDIATED SILVER NANOPARTICLES FOR HYPERGLYCEMIC AND HYPERLIPIDEMIC CONTROL

Abstract

The present study was designed to evaluate the design and characterization of swietenia mahagoni jacq. mediated silver nanoparticles for hyperglycemic and hyperlipidemic control. Using the extraction methods like soxhlet extraction, benzene extraction, Ethanolic Extraction, Ethyl acetate extraction, petroleum ether extraction. Animals were randomly divided into 5 groups. Group 1- normal control, Group 2- diabetic control, Group3 –treatment control Swietenia mahagoni 100mg/kg, Group 4 – Swietenia mahagoni 200mg/kg treated group, Group 5 – Glibenclamide 5mg/kg. The levels of biochemical parameter, body weight, serum lipid profile, serum total cholesterol, serum glycerides, VLDL AND & HDL cholesterol, HDL cholesterol, Hemoglobin & glycated hemoglobin were examined in each of these groups. Chronic administration of swietenia mahagoni at a dose of 100mg/kg & 200mg/kg, p.o. for a period of 21 days markedly decreased the level of blood glucose level & lipid level. Phamacological studies were assessed for bio assessment, clinical trials, and toxicological studies.  Quantitative estimation of total phenolic and flavonoid like estimation of total phenolic content, total flavonoid content, HPTLC investigation of ethanol extract. Taken together, the results suggested that treatment reduced hyperglycemic and hyperlipidemic control. This study demonstrates the swietenia mahagoni jacq.  Mediated silver nanoparticles for hyperglycemic and hyperlipidemic control.