FORMULATION AND EVALUATION OF PIMENTA DIOICA BASED TOPICAL GEL FOR ANTI INFLAMMATORY ACTIVITY
DOI:
https://doi.org/10.65336/WJMS.2026.3703Keywords:
Pimenta dioica, Eugenol, Topical gel, Anti-inflammatory activity, Herbal formulation.Abstract
The present study aims to formulate and evaluate a topical gel containing Pimenta dioica extract for anti-inflammatory activity. The extract was incorporated into a suitable gel base using polymers such as carbopol, along with necessary excipients like preservatives, humectants, and neutralizing agents. The prepared gel formulations were evaluated for various physicochemical parameters including appearance, pH, viscosity, spreadability, homogeneity, stability, anti inflammatory activity and anti oxidant activity.
References
1. El Gizawy, H. A., Boshra, S. A., Mostafa, A., Mahmoud, S. H., Ismail, M. I., Alsfouk, A. A., ... & Al-Karmalawy, A. A. (2021). Pimenta dioica (L.) Merr. bioactive constituents exert anti-SARS-CoV-2 and anti-inflammatory activities: molecular docking and dynamics, in vitro, and in vivo studies. Molecules, 26(19), 5844.
2. Lorenzo-Leal, A. C., Palou, E., López-Malo, A., & Bach, H. (2019). Antimicrobial, cytotoxic, and anti‐inflammatory activities of Pimenta dioica and Rosmarinus officinalis essential oils. BioMed research international, 2019(1), 1639726.
3. Monzote, L., Machín, L., González, A., Scull, R., Gutiérrez, Y. I., Satyal, P., ... & Setzer, W. N. (2023). Eugenol-Rich essential oil from Pimenta dioica: in vitro and in vivo potentialities against leishmania amazonensis. Pharmaceuticals, 17(1), 64.
4. Prakash P, Gupta N. Therapeutic uses of clove (Syzygium aromaticum) and eugenol and clove oil in medicine and Antioxidant activity of eugenol: a structure–activity relationship study for anti microbial activity.
5. Shah VP, Elkins J, Williams RL. Evaluation of topical drug products: bioavailability and bioequivalence. The Design and Manufacture of Medicines.
6. Kaur, L. P., & Guleri, T. K. (2013). Topical gel: a recent approach for novel drug delivery. Asian journal of biomedical and Pharmaceutical Sciences, 3(17), 1-5.
7. Hawk, M. A., Gorsuch, C. L., Fagan, P., Lee, C., Kim, S. E., Hamann, J. C., ... & Schafer, Z. T. (2018). RIPK1-mediated induction of mitophagy compromises the viability of extracellular-matrix-detached cells. Nature cell biology, 20(3), 272-284.
8. Baliyan, S., Mukherjee, R., Priyadarshini, A., Vibhuti, A., Gupta, A., Pandey, R. P., & Chang, C. M. (2022). Determination of antioxidants by DPPH radical scavenging activity and quantitative phytochemical analysis of Ficus religiosa. Molecules, 27(4), 1326.
9. Blois, M. S. (1958). Antioxidant determinations by the use of a stable free radical. Nature, 181(4617), 1199-1200.
