Effect of Ascorbic Acid, Balanites aegyptiaca, and Strawberry Supplementation on Glycemic Control and Renal Function Biomarkers
Keywords:
Ascorbic acid, Balanites aegyptiaca, Strawberry, Renal biomarkers, Glycemic regulation.Abstract
This study investigated the effects of ascorbic acid, Balanites aegyptiaca, and strawberry supplementation on glycemic control and renal function biomarkers over a six-week experimental period. Glycated hemoglobin (HbA1c) showed a non-significant reduction among treated groups (P = 0.072). The control group recorded 4.2 ± 0.42%, compared with 3.8 ± 0.22% (ascorbic acid), 3.1 ± 0.44% (Balanites aegyptiaca), and 3.2 ± 0.22% (strawberry). In contrast, serum glucose levels were significantly decreased (P = 0.000). The control value was 114.03 ± 1.55 mg/dl, while levels declined to 107.75 ± 1.91 mg/dl with ascorbic acid, 100.0 ± 3.70 mg/dl with Balanites aegyptiaca, and 102.51 ± 2.08 mg/dl with strawberry, representing a maximal reduction of approximately 14 mg/dl in the Balanites aegyptiaca group. Serum urea levels differed significantly among groups (P = 0.000), decreasing from 41.81 ± 0.71 mg/dl in the control group to 35.36 ± 1.77 mg/dl (ascorbic acid), 39.11 ± 1.09 mg/dl (Balanites aegyptiaca), and 33.78 ± 0.48 mg/dl (strawberry), with the lowest value observed in the strawberry-treated group. Serum creatinine levels were also significantly reduced (P = 0.002), from 0.86 ± 0.10 mg/dl in controls to 0.60 ± 0.017 mg/dl (ascorbic acid), 0.65 ± 0.03 mg/dl (Balanites aegyptiaca), and 0.67 ± 0.08 mg/dl (strawberry). Weekly trend analysis demonstrated gradual and sustained reductions in glucose, urea, and creatinine across treated groups over the six-week period. Overall, Balanites aegyptiaca exhibited the strongest hypoglycemic effect, ascorbic acid produced the greatest reduction in creatinine, and strawberry supplementation showed the most pronounced decrease in urea levels. These findings support the beneficial biochemical effects of these natural interventions on glucose homeostasis and renal function.
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